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Doctors typically give Tysabri to people who havent responded well or are intolerant to TNF blockers, immunomodulators, or corticosteroids

10.3945/ajcn.112.056382 [DOI] [PubMed] [Google Scholar] 21

Unlike its parent protein, fragment 176-191 has been found to avoid certain effects, such as increasing insulin-like growth factor-1 (IGF-1) levels, affecting carbohydrate metabolism, reducing insulin sensitivity, and promoting long bone growth