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waler klower Wolters Kluwer - Combining Domain Expertise With Advanced Technology Wolters Kluwer Legal & Regulatory

Name: waler klower Wolters Kluwer - Combining Domain Expertise With Advanced Technology Wolters Kluwer Legal & Regulatory
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Description

IL-1 ubiquitylation on lysine K133 promotes IL-1 turnover, and loss of IL-1 K133 ubiquitylation via the generation of Il1b K133R/K133R mice enhances i) pro-IL-1 protein levels, ii) the capacity of IL-1 to be activated following NLRP3 triggering, and iii) increases levels of precursor and activated IL-1 following LPS injection