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As a model for physiological conditions the cancer cells were cultivated and treated with a 21% O 2 atmosphere, and as a model for hypoxic conditions the cancer cells were cultivated and treated with a 1% O 2 atmosphere

For example, GPx1 has been reported to prevent oxidative DNA mutations, which in turn may prevent the development of tumors [42], and research shows that overexpression of GPx1 can reduce tumor growth, indicating its inhibitory effect in tumorigenesis [43]

The carbon fluorinated polymeric unit, that is able to physically entrap molecular O 2 , was incorporated into the polymer backbone for selective delivery of O 2 to the target tissue

It is characterized by rapid progression, a poor prognosis, and early metastasis