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In preclinical studies, NAD+ augmentation protected against axonal degeneration, improved cardiac function in models of heart failure, and enhanced the function of aged immune cells

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106,107 The interplay between oxidative stress and mtDNA damage is bidirectional

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Modifications in gene expression occur to yield an increase in the content of HSP [30, 31], proteins that act as molecular chaperones, being crucial in helping the cellular remodelling processes of denatured proteins, independent of the training response [89, 91]

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Fragile X syndrome due to a missense mutation

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