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Deletion of the regulatory domain in the pyridoxal phosphate-dependent heme protein cystathionine beta-synthase alleviates the defect observed in a catalytic site mutant

Monitoring PpIX biosynthesis in vivo by real-time FL/PA duplex imaging As oxidative stress is a key to the synergistic effect of IIT and 5-ALA-PDT for enhanced therapeutic efficacy 37,47,48 , we explored the metabolic dynamics of PpIX and O 2 generation to validate the feasibility for PpIX synthesis regulation and optimizing treatment parameters in vivo

Sucquart IE, Coyle C, Rodriguez Paris V, Prescott M, Glendining KA, Potapov K, et al

These alterations hinder normal neuromuscular signaling, ultimately leading to the onset and development of MG