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Anti-endothelial cell autoantibodies through ADCC, anti-endothelin, and anti-angiotensin agonistic antibodies, cytolytic CD4+ T cells, / T cells, and NK cells have been described as effector of endothelial cell (EC) activation and/or damage [7, 64,65,66,67] If this is true, then vasculopathy follows innate and adaptive immune responses (Fig