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Without adequate closing pressure from the lower esophageal sphincter, stomach acid inevitably escapes into the esophagus regardless of how effectively medications reduce overall acid production

Although they are often grouped together, they do not work the same way

rather, we intend for the proposed policy described above to address circumstances not addressed in that rulemaking (that is, we intend to address circumstances of single source drugs when negative or zero manufacturer's ASP data is reported for some, but not all NDCs, and of multiple source drugs when negative or zero manufacturer's ASP data is reported for some, but not all NDCs and the absence of such data from the calculation of the payment limit does not result in a significant change in the payment limit compared to the payment limit of the previous quarter) and thus fill a policy gap

Future studies need to be perform to further understand the role of obesity and complex effects on the intestine and their subsequent impact on bone health