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An absence of intrinsic factor is the most common cause of pernicious anemia

Proper medical oversight during administration minimizes these risks

Indeed, in our first on-treatment analysis at week 208, weight loss was greater (11.7% for semaglutide) compared with the in-trial analysis (10.2% for semaglutide)

What we are reporting is that the pattern is consistent enough across our patient population to make us think the combination is worth considering in carefully selected cases, while acknowledging that we cannot yet quantify the effect with the rigour that randomized trial evidence would provide