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Yang Y, Tai W, Lu N, Li T, Liu Y, Wu W, et al

Both aerobic and resistance exercise results in a significant increase in GH secretion, being its level correlated with exercise intensity [42, 43]

This browning is mediated through multiple pathways including SIRT1/PGC-1 activation, increased expression of thermogenic genes (UCP1, PRDM16, PPAR), and enhanced mitochondrial biogenesis

Peer review Peer review information Nature Communications thanks Weiqin Chen, Neil Kaplowitz, Hozumi Motohashi and the other, anonymous, reviewer(s) for their contribution to the peer review of this work