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This phase tests commitment

Biochim Biophys Acta 1830:31653172

An itaconate derivative, 4-octyl itaconate (4-OI), has been proven to promote ferroptosis by selectively degrading anti-ferritin, GPX4, solute carrier family 40 member A1 (SLC40A1), and organelles under safe and effective conditions, thus eliminating MDR RB cells, which may provide clinical workers with new targets for the treatment of acquired drug resistance (146)

In this work, we evaluate potential disease-modifying drugs tested in clinical trials and present updated information on drugs now undergoing clinical review [141]