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Hazard ratios decreased while using riluzole for the first 6 months of assessment but increased when measured out to 18 months, at which point the survival benefit was no longer statistically significant [116]

Further comprehensive research focusing on untouched areas of GBA may provide a better management strategy for PD and significantly improve patients quality of life

By constructing l-lactate sodium derivatives, numerous potential non-histone sites have been identified [22], further affirming their significance beyond histones

Mechanistically, MeCbl in base-off conformation coordinates to Cys180 site in GSDME and thereby prevents its recognition and cleavage by caspase-3 or GzmB