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WrightAHillierALambertJMwacalimbaKLloydNKagiwadaTet al

Neurological manifestations of B(12) deficiency with emphasis on its aetiology

ES2 is a senolytic peptide that targets FOXO4 CR3 but exhibits relatively poorer selectivity for senescent cells compared to FOXO4-DRI 25 (Table S1)

The trade-off is that nasal delivery is limited by the volume that can be administered per spray (100 microliters) while oral delivery can accommodate larger doses