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Clinically, Epi_2 tumors are associated with lymph-node metastasis and refractoriness to both immune-checkpoint blockade and anti-EGFR therapies (54), implying that therapeutic targeting of cuproptosis escape mechanisms could reverse such resistance

For the most part, L-lactate can be utilized as a preferred energy substrate of neurons for meeting the energy demand (19, 20) or act as the novel hormone-like effect called lactormone (21, 22)

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