acetaminophen glutathione toxicity Pathway (toxic doses), Pharmacokinetics Too much paracetamol = dangerous
Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Acetaminophen overdose resulting in massive hepatic necrosis. Note the scant residual periportal hepatocytes. #liverpath #hepatology Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors
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