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The colonies were let to grow for 23 days

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Crucially, pharmacological inhibition of CFTR in the PDECs (using CFTRinh-172) led to a ~54% reduction in insulin secretion from the underlying islets, whereas direct application of inhibitor to islets alone had no effect, underscoring a ducto-insular cross-talk mediated by CFTR function

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The IRF8 has been identified as a crucial player in normal bone marrow formation and the secretion of certain pro-inflammatory type 1 cytokines, like IL-12p40 and CCL5 [791]

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