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These fatty acids integrate into membrane phospholipids, alter receptor clustering and lipid-raft composition, and thereby modulate TLR4 signalling while improving redoxmetabolic stability [52,259]

Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11 (Liu Y