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2025;15 doi: 10.3390/nano15040255

The sensitivity of the spin-trapping technique is negatively affected by the dismutation of -H spin-adducts to nitrones and hydroxylamines 8,11 , whereas analyses in biological matrices are further complicated by the propensity of nitroxides to undergo one-electron reduction or oxidation either to EPR-silent hydroxylamines or to oxoammonium salts 12,13,14

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Inhibition of COX-2 by NSAIDs blocks PG production at sites of inflammation, whereas inhibition of COX-1 in other tissues (platelets and the gastroduodenal mucosa) leads to common adverse effects of NSAIDs, such as bleeding and gastrointestinal ulceration ( Owing to the adverse effects of NSAIDs and corticosteroids, disease-modifying antirheumatic drugs (DMARDs), a class of immunosuppressive and immunomodulatory agents, are developed to prevent and relieve RA aggression