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This study uniquely explores the effects of melatonin on newly discovered cell death pathways, cuproptosis and ferroptosis, in the context of ovarian aging, providing novel insights into potential mechanisms for improving oocyte quality in women of advanced maternal age undergoing ART

6-Gingerol was found to have no effects on the viability of HTR8 cells in concentrations up to 20 M (Supplementary Figure S1B)