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EGFR-T790M Mutation-Derived Interactome Rerouted EGFR Translocation Contributing to Gefitinib Resistance in Non-Small Cell Lung Cancer

Mechanistically, PA disrupts intracellular iron homeostasis via ER calcium release, upregulates transferrin (TF)-mediated iron transport, and ultimately triggers ferroptotic death through iron overload ( 2.4 Induction of cell cycle arrest Cell cycle arrest, achieved by downregulating cyclins and cyclin-dependent kinases (CDKs), represents a key anti-cancer strategy

PNAS 107:1083710841

In effect, thioctic acid acts as an amplifier, making the glutathione work harder and last longer than it would on its own