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They investigated if miR-148a and miR-152 inhibited PI3K/AKT pathway via targeting IRS-1 using IRS-1 loss- and gain-of-function experiments in BC cells

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AAV-mediated gene therapy for AIP utilizing recombinant AAV8-based serotype vector encoding murine HMBS (rAAV2/8- HMBS ) under the liver-specific transcriptional control of a hepatocyte enhancer and promoter has been tested in mice with AIP

These concepts, outlined in Figure 1, are relevant for our discussion