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ERN1 gene), and pancreatic ER kinase (PERK

These DAMs showing the highest variations, representing the main downregulated or upregulated metabolites across all samples, mainly belonged to the lipids, amino acids, peptides, analogs, carbohydrates, carbonyl compounds, phenols or flavonoids, indicating their significance as the characteristic metabolites

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The cells were maintained at 37C in an atmosphere of 5% CO2 in RPMI-1640 (Thermo Fisher Scientific, Inc., Waltham, MA, USA) with 10% fetal bovine serum (FBS