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Notably, after BHB is taken up by monocarboxylate transporter 1 (MCT1), which is specifically expressed in brain endothelial cells, it can upregulate the expression of ZO-1 by enhancing the local -hydroxybutyrylation of H3K9 at the TJP1 gene promoter, promoting the repair of the bloodbrain barrier after ischaemic stroke (99)

Liver is also a great source of folic acid and all of the B vitamins (particularly vitamin B12), which help with fatigue, mental ability and nerve health, as well as preventing anemia

A clinical trial has shown that the use of rhIL-11 can directly or indirectly induce cardiotoxicity, and the use of rhIL-11 in older and frail patients may cause or aggravate existing heart failure diseases (such as potential heart disease, pulmonary infection, etc.) [22] Thus it can be seen that the related toxicity caused by IL-11 often exceeds its limited efficacy

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