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Specifically, IL-4 promotes an anti-inflammatory phenotype by upregulating Arg1 [88], whereas IFN- induces a proinflammatory state, leading to the release of TNF- and IL-6 and the upregulation of MHC-II, which contributes to neuroinflammation [89]

A loading dose done for a week can be anywhere from 4g spread through the week for a small person (under 170), to 6g for a medium person (under 200), all the way to 10g for someone in the 250lb range

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However, under the MDD pathological condition, due to the decreased expression of EAATs in astrocytes, excessive glutamate in the synaptic cleft activates synaptic mGluRs, which leads to neuronal excitotoxicity