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NNMT is a known drain on NAD+, and 5-Amino-1MQ appears to inhibit this process by helping maintain more usable NAD+ within cells

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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

Using these concentration we have not yet perceived any of the reported adverse affects, including hypoglycaemias, retinopathies or any others