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SKU: 46186777658
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Cottrill, K

Further research has found that GA inhibited the interaction between P-selectin and platelets in HL60 cells, thereby preventing platelet activation ( 2+ level by inhibiting phosphorylation of Protein Kinase C alpha (PKC) and p38 mitogen-activated protein kinase (p38 MAPK) in platelets, as well as phosphorylation of Akt and glycogen synthase kinase 3 beta (GSK3), leading to a significant reduction in ADP- and U46619-induced platelet aggregation and platelet P-selectin expression in a concentration-dependent manner (Chang et al., 2012b)