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Recordings of brain swelling were performed in rats before sacrifice after complete calvariectomy was performed (Gojkovic et al., 2021a

Nature 500 , 415421 (2013)

They work by stimulating alpha-2 receptors in the brain, which reduce sympathetic outflow and norepinephrine release, thereby decreasing sympathetic activity and leading to effects such as reduced blood pressure, decreased heart rate, and alleviated withdrawal symptoms (92)