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Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]

Also as a second opinion or as an addition to your treatment (e.g

& Brennan, M

30 KRAS G12D inactivation, in contrast, downregulated global protein glycosylation, suggesting that KRAS G12D -mediated glucose utilization via HBP is essential for O -GlcNAcylation