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Brittle cornea syndrome is characterized by thin corneaa, early-onset progressive keratoglobus (cornea becomes extremely thin and change to a more globular shape than its normal gradual curve.) or keratoconus (begins to bulge into a cone-like shape), and blue sclerae (the white of the eye) Classic symptoms, such as hypermobile joints and hyperelastic skin, are also seen often

Mol Cell 51(2):236248 Suzuki S, Tanaka T, Poyurovsky MV et al (2010) Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species