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In genetically susceptible individuals with HLA-DR haplotypes impairing antigen presentation, these exposures provoke a failure to regulate the innate immune response, leading to a chronic, self-sustaining cascade of inflammation

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However, a very recent study suggested that there is no real effect once you take into consideration other lifestyle factors

Ceder S, Eriksson SE, Cheteh EH, Dawar S, Corrales Benitez M, Bykov VJN, et al