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In contrast, a randomized clinical trial in women with diminished ovarian reserve used 3 mg/day only during the ART cycle (approximately 35 weeks), reporting higher estradiol levels and improved oocyte and embryo quality without clear effects on pregnancy rates (Jahromi et al., 2017)

Extensive research has been conducted on the decrease in melatonin levels that occurs during both normal ageing and pathological ageing processes in the pineal gland, the brain, and numerous other tissues outside of the pineal gland, as well as in bodily fluids such as cerebrospinal fluid, plasma, saliva, and urine (Wu and Swaab 2005

The procedure only takes a few minutes and can be performed in an in-office clinic setting

RSL3 (MedChemExpress, HY-100218A) was dissolved in 10% DMSO, 40% PEG300, 5% Tween-80 and 45% saline and administered i.p