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It is also noted that while the widespread metabolic perturbations inherent to the disease were consistently observed across various tissues sampled from the Atm- KO mouse model, it is crucial to recognize that such analyses may have limitations in fully elucidating possible metabolic differences that could have pre-existed among distinct cell subtypes (e.g., neurons versus glia) located within different regions of the tissue

Hlskamp, M

F.CunsoloA.et al (2016)