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16, 433444 10.1007/BF01668498 [DOI] [PubMed] [Google Scholar] Mllgrd K., Lauritzen B., Saunders N

Notably, their effects extend beyond simple antioxidant activity, through multi-targeted mechanisms, they offer therapeutic approaches for intervening in the E-P-OS network

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For example, astrocyte-specific expression of SOCS3 in AD mouse models was shown to suppress not only GFAP induction and morphological hypertrophy but also neuroprotective and neurotoxic associated markers while simultaneously improving amyloid burden, synaptic function and cognition