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The hypothalamic-pituitary-adrenocortical system (HPA) plays a significant role in the cause and development of depression [131]

Bioenergetics, mitochondrial dysfunction, and oxidative stress in the pathophysiology of septic encephalopathy

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while measurements in awake rats suggested that only about 50% of active brains energy requirements can be supplemented by -hydroxybutyrate even at saturating plasma concentrations (17mM) -- the rest has to derive from glucose oxidation (Chowdhury et al., 2014)