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TNF also induces occludin degradation while promoting MLCK phosphorylation thus resulting in augmented paracellular permeability [154, 155]

Medical Management a) Anticonvulsants First-line treatment to calm overactive nerves: Carbamazepine (most effective) Oxcarbazepine , Gabapentin , Pregabalin , Phenytoin b) Muscle Relaxants Baclofen is often added when anticonvulsants alone are insufficient