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To confirm this hypothesis, we generated a novel 3x Flag-Bnip3 knock-in mouse model using CRISPR/Cas 9-based technology ( Flag-Bnip3 ki/ki , Flag-Bnip3 ki/+ , Flag-Bnip3 /

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2020;8(2):e933

Interactions between ferroptosis-related signaling pathways in cancer drug resistance Notably, interactions among ferroptosis-related pathways, especially GPX4, NRF2, and iron metabolism regulators, are pivotal in cancer drug resistance