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Key questions including the existence of lactyl-CoA in vivo, the physiological relevance of non-enzymatic lactylation, and the identification of specific reader proteins must be resolved before lactylation can be fully established as a stable and universal regulatory mechanism

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Microbial Therapies Building on extensive evidence linking gut dysbiosis to PD pathogenesis, microbial interventions have emerged as potential therapeutic strategies [19, 20, 21, 22, 123]

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