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Steurer, M

doi: 10.1038/nrc.2016.108

Erinacine C was mostly evaluated in vitro , with only two of the seven papers featuring in vivo experiments

In adipose and ovarian tissues, macrophages are abnormally activated and polarized toward a pro-inflammatory (M1) phenotype, secreting IL-6, TNF-, and other factors that exacerbate local and systemic inflammation and insulin resistance, potentially interfering with follicular development (18)