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Acknowledgements The work was financially supported by the Medical Research Council (UK Regenerative Medicine Platform Hub Acellular Smart Materials 3D Architecture, MR/R015651/1), the ERC PoC Grant NOVACHIP, and project number AOCMF-21-04S from the AO Foundation, AO CMF

Therefore, the focus was on therapeutic interventions published between January 2010 and November 2023, overlapping with the period of increasing IMF exposure

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Regression analyses were performed to examine the associations between different CTP parameters and outcomes