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It means one prior regulatory barrier changed

doi:10.2174/1381612826666200424180139 Park JM, Lee HJ, Sikiric P, Hahm KB

Realistic timeline based on preclinical data and community reports

Strong neurogenesis, angiogenesis, synaptogenesis, and antifibrosis of hepatocyte growth factor in rats brain after transient middle cerebral artery occlusion