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10.1371/journal.pone.0048924 PLoS ONE 177 SpencerP

In contrast, with aging, genotoxic stress, and senescence-associated secretory phenotype elevated macrophage CD38 levels promote the decline of NAD + and nicotinamide mononucleotide (NMN) levels in a CD38-dependent manner, in parallel with increased M1 macrophage polarization (37, 40)

If the confidence intervals do not fall outside the non-inferiority limit (10%), it can be concluded that the oral treatment is not inferior to the intramuscular treatment