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The terminal pathway of CS signaling involves the convergence of all three CS signaling pathways that form the final and lytic component of the CS called the MAC, which forms pores in the targeted microbial surface ( Figure 2D ) (27)

It is composed of a hydrophobic wall (Phe564, Ile778, Leu781, and Tyr612), a polar wall (Asp563, Arg616, and Asn620), and a polar bottom (Asp764 and His617) [260]