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Targeting OXPHOS inhibits tumour growth in multiple PDX models of ER-positive BM Based on the findings from transcriptomic and metabolomics analyses, we hypothesised that OXPHOS could represent a therapeutic target in metastatic ER + BC

Another clinical challenge is the TSHT3 mismatch: while TSH reflects central (pituitary) regulation, it does not necessarily correspond to peripheral thyroid hormone activity, especially in the altered hormonal environment induced by ketosis [114]

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However, in that study, the neuronal and glial cells were co-treated with cytotoxic concentrations of H 2 O 2 , and therefore it is unlikely that GGC could produce beneficial effects on GSH in this condition