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G6PD catalyzes the rate-limiting step in the pentose phosphate pathway, which provides nucleotide precursors for DNA replication as well as cytosolic reducing equivalents of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)

rescue therapy aims to salvage neurons and slow the progression of the disease whereas restoration therapy focuses on replacing neurons

The freely diffusible and highly reactive diatomic gas nitric oxide (NO) is produced during infection (Iyengar, Stuehr and Marletta, 1987