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2023;19(37):e2301420

The author reported augmented deposition of collagen, oxidative stress, and phosphorylated p38 protein in DNP rats, which were reversed by melatonin ( Melatonin alone or in combination with drugs such as gabapentin enhanced the hepatic gene expression of peroxisome proliferatoractivated receptor and mitochondrial transcription factor-A

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Here, we demonstrated that preferential accumulation of peroxidized phospholipids and loss of the antioxidant enzyme glutathione peroxidase 4 (GPX4) were responsible for vulnerability of midbrain dopaminergic neurons and progressive motor dysfunctions in a mouse model of PD