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10.1073/pnas.96.26.14967 49 SuiX.ZhangR.LiuS.DuanT.ZhaiL.ZhangM.et al (2018)

found no CHAC1 upregulation after exposing HT-1080 (fibrosarcoma cell line) and Calu-1 (non-small-cell lung cancer) cells to artesunate, whereas in more recent studies, a significant increase in CHAC1 expression in Burkitts lymphoma cells was observed (Wang et al., 2019)