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Therefore, important blood components, including plasma proteins, clotting factors, and platelets, are returned to the individual being treated

In visceral but not subcutaneous WAT, the connection between adipocyte hypertrophy and inflammation facilitated by M1-like macrophages and/or B-cells may be involved in insulin resistance [64]

ROS generated during metabolic reprogramming (e.g., enhanced glycolysis, mitochondrial dysfunction) can amplify inflammatory signals, while inflammation further exacerbates metabolic dysregulationforming a vicious cycle of metabolic abnormalitiesinflammationimmune dysregulation (111)

Feng L, Li B, Cai M, Zhang Z, Zhao Y, Yong SS, Tian Z