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These compounds work by covalent interaction with the selenocysteine active site of GPX4

doi: 10.1016/j.apsb.2016.07.016 168 HardieDG

Induction of apoptosis by VV in macrophages induces a decrease in mitochondrial membrane potential and is associated with altered levels of Bcl-x (L) an anti-apoptotic member of the Bcl-2 family