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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

Transcription from P2, on the other hand, produces a dominant negative form of LEF1

doi: 10.1016/j.jaut.2021.102630 70 LevringTBHansenAKNielsenBLKongsbakMvon EssenMRWoetmannAet al

Although the aetiology is unknown and the pathophysiology is poorly understood, PSC is regarded as an autoimmune liver disease based on a strong immunogenetic background