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For instance, the Infinium assay reported higher DNA methylation levels for CpGs that other assays identified as lowly methylated, while reporting slightly reduced DNA methylation levels for highly methylated CpGs

In absence of MGMT-mediated demethylation in response to O 6 -Me guanine, MMR was shown to proceed in a futile cycle where thymidine mis-paired to methylguanine is continually excised and replaced