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NADH then donates those electrons to the mitochondrial electron transport chain, creating the gradient that powers ATP synthesis

Acetylering beschermt de gevoelige SH-groep in gereduceerd glutathion, waardoor deze alleen binnen de cellen actief wordt

JAMA 2000;284:472-7.

Currently, research is focused on the development of highly selective inhibitors targeting specific HDAC subtypes, particularly HDAC6, which retain immunomodulatory activity while substantially reducing toxicity [243, 244]